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Cat. No.	Product Name	Target	Signaling Pathways
T82763	CD33 splicing modulator 1 hydrochloride
	"CD33splicing modulator 1 (Compound 1) hydrochloride 是一种调节CD33/Siglec 3活性的化合物。CD33/Siglec 3 为髓系细胞表面受体，涉及小胶质细胞功能。该化合物通过提升细胞mRNA池中外显子2的剪接变异，展现在神经退行性疾病研究中的应用潜力，包括阿尔茨海默病。"
T62612	CD33 splicing modulator 1
	CD33 splicing modulator 1 (Compound 1) 是一种 CD33 splicing modulator。CD33/Siglec 3 是一种已知可调节小胶质细胞活性的髓系细胞表面受体。CD33 splicing modulator 1 加强了细胞 mRNA 池中外显子 2 的跳跃。CD33 splicing modulator 1 具有潜力进行包括阿尔茨海默病在内的神经退行性疾病的研究。

化合物

CD33 splicing modulator 1 hydrochloride

Cat.No: T82763

Synonym:

Target:

CD33 splicing modulator 1

Cat.No: T62612

Synonym:

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Cat. No.	Product Name	Species	Expression System
TMPY-03805	Siglec-3/CD33 Protein, Human, Recombinant (His) CD33 molecule,SIGLEC3,	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is AAH28152.1.
TMPY-04805	Siglec-3/CD33 Protein, Human, Recombinant SIGLEC3,Siglec-3,CD3...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 27.4 kDa and the accession number is AAH28152.1.
TMPY-04952	Siglec-3/CD33 Protein, Human, Recombinant (His), Biotinylated CD33 molecule,p67,SIGLEC3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is AAH28152.1.
TMPY-02304	Siglec-3/CD33 Protein, Mouse, Recombinant (His) gp67,CD33 molecule,Siglec-3	Mouse	HEK293 Cells
	Siglec-3/CD33 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is Q63994-1.
TMPY-04808	Siglec-3/CD33 Protein, Mouse, Recombinant gp67,CD33 molecule,Siglec-3	Mouse	HEK293 Cells
	Siglec-3/CD33 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.6 kDa and the accession number is Q63994-2.
TMPY-05572	Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated Siglec-3,p67,CD33 molecu...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
TMPY-03694	Siglec-3/CD33 Protein, Human, Recombinant (mFc) p67,Siglec-3,CD33 molecu...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 29.5 kDa and the accession number is AAH28152.1.
TMPY-02263	Siglec-3/CD33 Protein, Mouse, Recombinant (hFc) CD33 molecule,gp67,Siglec-3	Mouse	HEK293 Cells
	Siglec-3/CD33 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.6 kDa and the accession number is Q63994-1.
TMPY-05381	Siglec-3/CD33 Protein, Human, Recombinant (hFc) p67,CD33 molecule,SIGLEC3	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.5 kDa and the accession number is AAH28152.1.
TMPY-05571	Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated CD33 molecule,Siglec-3,p...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
TMPK-01300	Siglec-3/CD33 Protein, Cynomolgus, Recombinant (His) Siglec-3,CD33,Siglec...	Cynomolgus	HEK293 Cells
	Siglec-3/CD33 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.83 kDa and the accession number is XP_005590138.1.
TMPJ-00537	Siglec-3/CD33 Protein, Human, Recombinant (hFc & His) Myeloid Cell Surface Antigen CD33,CD3<...	Human	HEK293 Cells
	CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are c...
TMPK-00844	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi) p67,CD33 molecule,FLJ00391,Si...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1.
TMPK-00846	Siglec-3/CD33 Protein, Human, Recombinant (aa 18-259, hFc) CD33,CD33 molecule,gp67,...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (aa 18-259, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.6 kDa and the accession number is P20138-1.
TMPK-00843	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), FITC-Labeled CD33,CD33 molecule,gp67,...	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1.
TMPK-00845	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated Siglec3,p67,FLJ00391,Siglec	Human	HEK293 Cells
	Siglec-3/CD33 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.6 kDa and the accession number is P20138-1.
TMPY-02409	Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His) CD33 molecule	Cynomolgus,Rhesus	HEK293 Cells
	Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is EHH59833.1&EHH30318.1.
TMPK-01295	Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi) CD33 molecule-like 3,Siglec	Cynomolgus	HEK293 Cells
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mam...
TMPK-00231	Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated CD33 molecule-like 3,Siglec	Mouse	HEK293 Cells
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylate...
TMPK-00217	Siglec-15 Protein, Human, Recombinant (His & Avi) Siglec15,CD33 molecule-like 3...	Human	HEK293 Cells
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates..
TMPK-01296	Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated CD33 molecule-like 3,CD3...	Cynomolgus	HEK293 Cells
	Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed...
TMPJ-00217	Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated CD33L3,Siglec-15,Sialic ...	Human	HEK293 Cells
	Siglec-15 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Fc-Avi tag. The predicted molecular weight is 58-75 KDa and the accession number is Q6ZMC9.
TMPJ-00225	Siglec-15 Protein, Mouse, Recombinant (His) Siglec-15,Sialic acid-binding Ig-like lectin 15,CD<...	Mouse	HEK293 Cells
	Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type I...
TMPJ-00434	Siglec-15 Protein, Cynomolgus, Recombinant (His) Siglec-15,CD33L3,Sialic ...	Cynomolgus	HEK293 Cells
	Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47.
TMPY-05366	Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated CD33 molecule	Cynomolgus,Rhesus	HEK293 Cells
	Siglec-3/CD33 Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.3 kDa and the accession number is XP_005590138.1.
TMPY-03961	Siglec-6 Protein, Human, Recombinant (hFc) sialic acid binding Ig like lectin 6,CD33L...	Human	HEK293 Cells
	Siglec-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.7 kDa and the accession number is O43699-3.
TMPJ-01254	Siglec-F Protein, Mouse, Recombinant (His) sialic acid binding Ig like lectin 8,SAF2,SIGLEC-8,...	Mouse	HEK293 Cells
	Siglec 5 to 11 share a high degree of sequence similarity with CD33/Siglec-3 both in their extracellular and intracellular regions. They are collectively referred to as CD33-related Siglecs. One remarkable feature of the CD33-related Siglecs is their differential expression pattern within the hematopoietic system. This fact, together with the presence of two conserved immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their cytoplasmic tails, suggests that CD33-related Siglecs are involv...
TMPY-06986	FGF-8b Protein, Human, Recombinant NEWENTRY,fibroblast growth factor 8 (androgen-induced),FGF-8...	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPY-00132	Mesothelin Protein, Human, Recombinant MPF,SMRP,Mesothelin	Human	HEK293 Cells
	Mesothelin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is Q13421-3.
TMPY-04935	CD47 Protein, Human, Recombinant (aa 1-139, His) MER6,CD47 molecule,IAP,OA3	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q08722-3.
TMPY-03763	Neuropilin-2 Protein, Human, Recombinant (hFc) Neuropilin-2,NPN2,neuropilin 2,PRO2714,VEGF165R2,NP2	Human	HEK293 Cells
	Neuropilin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 120.7 kDa and the accession number is O60462-3.
TMPY-01897	PRSS3 Protein, Human, Recombinant (His) PRSS4,TRY4,TRY3,RP11-176F3.3,T9,M...	Human	HEK293 Cells
	Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ...
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His) PN,OSF-2,OSF2,periostin,periostin, osteoblast specific facto...	Human	HEK293 Cells
	Periostin/OSF-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is Q15063-3.
TMPY-00892	Neuropilin-2 Protein, Human, Recombinant (His) NP2,PRO2714,VEGF165R2,neuropilin 2,NPN2,Neuropilin-2	Human	HEK293 Cells
	Neuropilin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is O60462-3.
TMPY-05191	CD47 Protein, Human, Recombinant, Biotinylated CD47 molecule,MER6,OA3,IAP	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
TMPY-04683	CD47 Protein, Human, Recombinant MER6,CD47 molecule,OA3,IAP	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
TMPY-00072	GITR/TNFRSF18 Protein, Human, Recombinant (His) AITR,GITR-D,tumor necrosis factor receptor superfamily, memb...	Human	HEK293 Cells
	GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
TMPY-01180	CD86 Protein, Human, Recombinant (His) CD86 antigen,B70,B7.2,B7-2,CD28LG2,LAB72	Human	HEK293 Cells
	CD86 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P42081-3.
TMPY-05748	CD45 Protein, Human, Recombinant (aa 26-577, His) L-CA,T200,LCA,B220,protein tyrosine phosphatase, receptor ty...	Human	HEK293 Cells
	CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.
TMPY-04142	RANK/TNFRSF11A Protein, Human, Recombinant (hFc) OPTB7,OFE,OSTS,LOH18CR1,FEO,TRANCER,tumor necrosis factor re...	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.
TMPJ-01099	IL-15RA Protein, Human, Recombinant (hFc, Human Cells) interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece...	Human	HEK293 Cells
	Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun...
TMPY-04298	CDCP1 Protein, Human, Recombinant (His) TRASK,CD318,CUB domain containing protein 1,SIMA1	Human	HEK293 Cells
	CDCP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.4 kDa and the accession number is Q9H5V8-3.
TMPY-00357	HNT/NTM Protein, Human, Recombinant (His) HNT,NTRI,IGLON2,neurotrimin	Human	HEK293 Cells
	HNT/NTM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.3 kDa and the accession number is Q9P121-3.
TMPY-00480	NCAM1 Protein, Human, Recombinant (His) neural cell adhesion molecule 1,CD56,MSK39,NCAM	Human	HEK293 Cells
	NCAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.1 kDa and the accession number is P13591-3.
TMPK-00447	CD45 Protein, Human, Recombinant (aa 26-577, hFc) CD45,CD45R,LCA,PTPRC,L-CA,T200,B220,GP180,LY5,EC 3....	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (aa 26-577...
TMPY-01268	SMYD3 Protein, Human, Recombinant (GST) SET and MYND domain containing 3,ZMYND1,KMT3	Human	Baculovirus Insect Cells
	SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional reg...
TMPY-03621	EphB2 Protein, Mouse, Recombinant (hFc) Tyro5,Erk,Qek5,ETECK,Hek5,Drt,EPH receptor B2,Nuk,Prkm5,Sek<...	Mouse	HEK293 Cells
	EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.6 kDa and the accession number is P54763-3.
TMPJ-01288	KLF6 Protein, Human, Recombinant CPBP,GC-Rich Sites-Binding Factor GBF,Suppressor of Tumorige...	Human	E. coli
	Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by spleen, thymus, prostate, testis, small intestinem and colon. However, it is weakly expressed in the pancreas, lung, liver, heart, and skeletal muscle. KLF6 functions as a transcriptional activator and could play a role in B-cell growth and development. Defects in KLF6 will resul...
TMPY-04386	EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) PCBC,CAPB,Hek5,EK5,EPHT3,EPH receptor B2,Tyro5,DRT,...	Human	Baculovirus Insect Cells
	EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.2 kDa and the accession number is P29323-3.
TMPY-03149	CDCP1 Protein, Human, Recombinant (mFc) TRASK,SIMA135,CD318,CUB domain containing ...	Human	HEK293 Cells
	CDCP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.4 kDa and the accession number is Q9H5V8-3.
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